Colorado Care Network

Five domains, twenty-five cohorts

The network is organized into five domains with five cohorts in each. The first three domains describe patients and get care maps. The last two describe the providers who serve them and get rosters. Every care map draws its people from domains four and five. The [structure page](/structure/) explains the format, the process for starting a cohort, and the naming conventions.

All twenty-five cohorts

Five launch with the founding cohort. Five are forming, one per domain, opened 2026-10-29 and looking for leads. The other fifteen are seeking leads: the convener wrote and reviewed a first map or roster so every case and every referral has a home in the grid, and each one is waiting for a member to lead it. The structure page explains how a cohort moves from a first map to running.

1Complex disease
Patients, care maps
Connective tissue1.1 LaunchhEDS, HSD, Marfan, Loeys-Dietz and heritable aortic disease, and the patients being sorted among themNonspecific symptoms1.2 FormingFatigue, pain, dysautonomia or cognitive symptoms with no unifying diagnosis after a standard workupSpecific signs1.3 Seeking a leadAn objective finding that points somewhere: an odd lab, an imaging finding, a dysmorphic feature, a family pattern with uninformative testingProgressive monogenic disease1.4 Seeking a leadDiagnosed, progressive, multiorgan monogenic disease where the plan is coordination, surveillance and quality of lifeManagement and surveillance1.5 Seeking a leadNF1, Marfan after diagnosis, Turner, 22q11.2 and similar in adults: lifelong multi-organ surveillance
2Treatable monogenic disease
Patients, care maps
Lysosomal storage disorders2.1 Seeking a leadPompe, Gaucher, Fabry, ASMD, attenuated MPS, alpha-mannosidosis: ERT, substrate reduction and chaperonesHypophosphatasia2.2 Seeking a leadHPP and the related bone and mineral disorders, including X-linked hypophosphatemiaTransthyretin amyloidosis2.3 ForminghATTR, with HoFH, familial chylomicronemia and lipodystrophy on the same infusion and specialty pathwayInherited metabolic disease2.4 Seeking a leadPKU, urea cycle disorders, homocystinuria, CTX, acute hepatic porphyria, Wilson, AATD, hemochromatosisNeurogenetic2.5 LaunchAdult SMA, Friedreich ataxia, primary mitochondrial disease, Huntington, and the treatable diagnosis in a progressive picture
3Population genetics
Patients, care maps
Hereditary cancer risk3.1 LaunchLynch, BRCA1/2, PALB2 and other cancer syndromes, plus cascade testingComprehensive genetic risk3.2 FormingProactive exome or genome in healthy adults: ACMG secondary findings, FH, inherited cardiomyopathy and arrhythmiaPolygenic risk score3.3 Seeking a leadPRS for coronary disease, breast and prostate cancer and type 2 diabetes, and how they stack with monogenic results and family historyPharmacogenomic profile3.4 Seeking a leadActionable drug-gene results applied to current and future prescribingPreconception carrier screening3.5 Seeking a leadExpanded carrier screening, preconception counseling and family planning
4Diagnostic support
Providers, rosters
Advanced imaging4.1 LaunchSpecialized MRI protocols, cardiac MRI, nuclear and vascular imagingProcedural studies4.2 FormingEcho, CPET, electrophysiology, PFTs, EMG and NCS, autonomic and tilt testing, skin and muscle biopsyEsoteric assays4.3 Seeking a leadBiochemical genetics, specialty immunology, endocrine and autoimmune testing, sequencing and reanalysis labsClinical expertise4.4 Seeking a leadCash-basis genetics and subspecialty consults: variant interpretation, second opinions, academics who'll take a case from an anchorEmpiric therapies4.5 Seeking a leadInfusion centers, compounding and specialty pharmacy, expanded access, trial enrollment, off-label and compassionate use
5Private practice
Providers, rosters
Primary care5.1 FormingDPC and concierge physicians and APPs who anchor a care mapSpecialist5.2 LaunchCash-pay or hybrid cardiology, neurology, rheumatology, GI, endocrinology and othersTherapists5.3 Seeking a leadPhysical, occupational, speech and pelvic floor therapistsCounselor5.4 Seeking a leadGenetic counselors, psychologists, psychiatrists and mental-health counselorsResource5.5 Seeking a leadDietitians, care navigators, patient advocates, social work, pharmacists, and the patient organizations that stay independent

Private practice eligibility is specific: the clinician founded or co-founded the practice, and more than half of its revenue comes from patients rather than payers. Diagnostic centers qualify by publishing cash prices and running requested protocols.

Conditions still to place

Several adult-treatable conditions sit between cohorts and will be placed as the domains fill out: cystic fibrosis (CFTR modulators), hereditary angioedema, MODY, sickle cell disease, and atypical hemolytic uremic syndrome. Primary mitochondrial disease and Huntington disease stay with the neurogenetic cohort until a broadly approved disease-modifying therapy exists.

Colorado Care Network. Five domains, twenty-five cohorts. Version 2026-10-30.