Colorado Care Network
Pinned

For the patients who don't fit.

Independent Colorado physicians, one paper a month, genetics in primary care. We work de-identified cases and turn them into care maps any clinician can use. No fee. No industry money.

The 34-year-old with hypermobility, POTS and a normal connective tissue panel. The neuropathy with a complete workup. The family with three cancers before 50. Start with the care map, then find a member who sees them.

Start here

Join the founding cohort

Six to eight physicians, mostly primary care, seated by invitation. First session early 2027.

Express interest

Sit in on a session

Any clinician or trainee. One hour on Teams. We confirm and send the link.

Request a seat

Get the monthly reading

The paper and the discussion prompts, once a month, from hello@.

Join the list

Find a member to send to

Members who take referrals, by cohort, specialty and town. Published prices, notes back to you.

Find a member

How the network works

Five domains, 25 cohorts, one journal club. Care maps recommend; they never require.

Read the structure

The grid

Five domains, five cohorts each. Domains 1 to 3 are patients and get care maps. Domains 4 and 5 are the clinicians, labs and centers who see them and get rosters. Every cell is a page you can use today.

1Complex disease
Patients, care maps
Connective tissue1.1 LaunchhEDS, HSD, Marfan, Loeys-Dietz and heritable aortic disease, and the patients being sorted among themNonspecific symptoms1.2 FormingFatigue, pain, dysautonomia or cognitive symptoms with no unifying diagnosis after a standard workupSpecific signs1.3 Seeking a leadAn objective finding that points somewhere: an odd lab, an imaging finding, a dysmorphic feature, a family pattern with uninformative testingProgressive monogenic disease1.4 Seeking a leadDiagnosed, progressive, multiorgan monogenic disease where the plan is coordination, surveillance and quality of lifeManagement and surveillance1.5 Seeking a leadNF1, Marfan after diagnosis, Turner, 22q11.2 and similar in adults: lifelong multi-organ surveillance
2Treatable monogenic disease
Patients, care maps
Lysosomal storage disorders2.1 Seeking a leadPompe, Gaucher, Fabry, ASMD, attenuated MPS, alpha-mannosidosis: ERT, substrate reduction and chaperonesHypophosphatasia2.2 Seeking a leadHPP and the related bone and mineral disorders, including X-linked hypophosphatemiaTransthyretin amyloidosis2.3 ForminghATTR, with HoFH, familial chylomicronemia and lipodystrophy on the same infusion and specialty pathwayInherited metabolic disease2.4 Seeking a leadPKU, urea cycle disorders, homocystinuria, CTX, acute hepatic porphyria, Wilson, AATD, hemochromatosisNeurogenetic2.5 LaunchAdult SMA, Friedreich ataxia, primary mitochondrial disease, Huntington, and the treatable diagnosis in a progressive picture
3Population genetics
Patients, care maps
Hereditary cancer risk3.1 LaunchLynch, BRCA1/2, PALB2 and other cancer syndromes, plus cascade testingComprehensive genetic risk3.2 FormingProactive exome or genome in healthy adults: ACMG secondary findings, FH, inherited cardiomyopathy and arrhythmiaPolygenic risk score3.3 Seeking a leadPRS for coronary disease, breast and prostate cancer and type 2 diabetes, and how they stack with monogenic results and family historyPharmacogenomic profile3.4 Seeking a leadActionable drug-gene results applied to current and future prescribingPreconception carrier screening3.5 Seeking a leadExpanded carrier screening, preconception counseling and family planning
4Diagnostic support
Providers, rosters
Advanced imaging4.1 LaunchSpecialized MRI protocols, cardiac MRI, nuclear and vascular imagingProcedural studies4.2 FormingEcho, CPET, electrophysiology, PFTs, EMG and NCS, autonomic and tilt testing, skin and muscle biopsyEsoteric assays4.3 Seeking a leadBiochemical genetics, specialty immunology, endocrine and autoimmune testing, sequencing and reanalysis labsClinical expertise4.4 Seeking a leadCash-basis genetics and subspecialty consults: variant interpretation, second opinions, academics who'll take a case from an anchorEmpiric therapies4.5 Seeking a leadInfusion centers, compounding and specialty pharmacy, expanded access, trial enrollment, off-label and compassionate use
5Private practice
Providers, rosters
Primary care5.1 FormingDPC and concierge physicians and APPs who anchor a care mapSpecialist5.2 LaunchCash-pay or hybrid cardiology, neurology, rheumatology, GI, endocrinology and othersTherapists5.3 Seeking a leadPhysical, occupational, speech and pelvic floor therapistsCounselor5.4 Seeking a leadGenetic counselors, psychologists, psychiatrists and mental-health counselorsResource5.5 Seeking a leadDietitians, care navigators, patient advocates, social work, pharmacists, and the patient organizations that stay independent

Why bother

Genome sequencing found a molecular diagnosis in 54 of 353 undiagnosed families, 15.3%, and more than half of those variants sat in regions the earlier testing never looked at (Pitsava 2025). Those patients were on somebody's panel the whole time. Primary care sees them first, and independent practice has the time to look.

What members get

A journal club

One hour a month on Teams: one paper or one de-identified case, and the same question every time, where is the genomic signal. CME is in the works.

Care maps

Three years of workup, treatment and follow-up for each patient cohort, every line cited. They recommend; they never require.

A roster that writes back

Specialists, labs and centers with published cash prices, who run the protocol you asked for and send the note back to you.

No fee, no sponsors

Free to join. No industry money, no payment for referrals in either direction, and the patient always picks the provider.

Colorado Care Network. Colorado Care Network. Version 2026-10-30.